Endodiabesity

The North West of England Endocrinology, Diabetes and Obesity Newsletter

BES 2010: Abstracts from the North West

Posted by Angela Paisley on 18 February, 2010

Adult GH replacement and risk of tumour recurrence: 15 years experience from a large single centre

Scott Mackenzie & Georg Brabant
Christie Hospital, Manchester, UK.

Endocrine Abstracts (2010) 21 P290

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Circadian and pulsatile secretion of copeptin, an arginine vasopressin (AVP) marker, argues against a physiological role of AVP in cortisol release

Ken Darzy1, Kashinath Dixit2, Stephen Shalet2, Nils Morgenthaler3 & Georg Brabant2
1Department of Endocrinology, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UK; 2Department of Endocrinology, Christie Hospital, Manchester, UK; 3Research Department, BRAHMS, AG, Berlin, Germany.

Endocrine Abstracts (2010) 21 P292

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Endocrine outcomes of pituitary surgery

Kate Millar1, Sanjaya Dissanayake1, Kaushik Ghosh1, Nisha Kaimal2, David Walmsley2, Kalpana Kaushal1 & Simon Howell1
1Royal Preston Hospital, Preston, UK; 2Royal Lancaster Infirmary, Lancaster, UK.

Endocrine Abstracts (2010) 21 P267

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Solitary pituitary metastasis from carcinoma of the prostate: a case report

Seleena Farook, Kanna Gnanalingham, Pyali Pal & Tara Kearney
Royal NHS foundation Trust Manchester, UK.

Endocrine Abstracts (2010) 21 P260

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Long-term unsynchronised transcriptional cycles in individual living pituitary cells

Claire Harper1, Barbel Finkenstadt2, Dan Woodcock2, Sonke Friedrichsen3, Sabrina Semprini4, Dave Spiller1, John Mullins4, David Rand2, Julian Davis3 & Mike White1
1University of Liverpool, Liverpool, UK; 2University of Warwick, Coventry, UK; 3University of Manchester, Manchester, UK; 4University of Edinburgh, Edinburgh, UK.

Endocrine Abstracts (2010) 21 P293

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Immuno-modulatory role of prolactin in immune tissues driven by the alternative promoter

Anne McNamara1, Raheela Awais1, Sabrina Semprini2, Claire Harper1, Karen Featherstone3, Dave Spiller1, Julian Davis3, John Mullins2 & Mike White1
1University of Liverpool, Liverpool, UK; 2University of Edinburgh, Edinburgh, UK; 3University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P299

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Adults with partial GH deficiency (GHD) show phenotypic dichotomy related to the timing of onset of the deficiency

Haliza Haniff1, Judith Adams2, Stephen Shalet3 & Robert Murray1,3
1Leeds Teaching Hospitals NHS Trust, Leeds, UK; 2University of Manchester, Manchester, UK; 3Christie Hospital NHS Trust, Manchester, UK.

Endocrine Abstracts (2010) 21 P301

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The tyrosine phosphatase, SHP-1, acts on multiple tyrosine kinase receptors to negatively regulate human cytotrophoblast proliferation

Karen Forbes, Laura Skinner, John Aplin & Melissa Westwood
University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P316

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Steroid analysis in patients receiving metyrapone therapy

Laura Owen1, David Halsall2, Alexandra Yates1 & Brian Keevil1
1University Hospital of South Manchester, Manchester, UK; 2Addenbrooke’s Hospital, Cambridge, UK.

Endocrine Abstracts (2010) 21 P332

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Reference range data on androsterone glucuronide in healthy male and female volunteers and clinical uses of the assay

Joanne Adaway1, Adrian Miller1, F C W Wu2 & Brian Keevil1
1University Hospital South Manchester NHS Foundation Trust, Manchester, UK; 2Central Manchester and Manchester Childrens University Hospitals NHS Foundation Trust, Manchester, UK.

Endocrine Abstracts (2010) 21 P333

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Determination of tandem mass spectrometry specific reference ranges for testosterone, androstenedione and DHEAS

Philip Macdonald1, Frederick Wu2, Laura Owen1 & Brian Keevil1
1University Hospital of South Manchester, Manchester, UK; 2Central Manchester and Manchester Children’s University Hospitals, Manchester, UK.

Endocrine Abstracts (2010) 21 P337

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A sensitive and specific tandem mass spectrometry assay for the measurement of salivary testosterone

Philip Macdonald, Laura Owen & Brian Keevil
University Hospital of South Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P338

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Is a raised DHEAS significant when analysed as part of an androgen profile?

Carrie Chadwick1 & Brian Keevil2
1Aintree University Hospital Trust, Liverpool, UK; 2South Manchester University Hospital Trust, Manchester, UK.

Endocrine Abstracts (2010) 21 P342

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Regulation of glucocorticoid receptor activity by cellular stress

Laura Davies, Malihah Sadeq, Constantinos Demonacos & Marija Krstic-Demonacos
University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P347

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Acute fatty liver due to poor diabetic control

Agnieszka Swiecicka & Manjunath Malige
Royal Bolton Hospital, Bolton, UK.

Endocrine Abstracts (2010) 21 P54

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Severe abdominal pain as presentation of Addison’s disease in undiagnosed case of autoimmune polyglandular disease

Bashir El-Mahmoudi, Tony Tetlow & Chaminda Jayawarna
Tameside General Hospital, Ashton-U-Lyne, Manchester, UK.

Endocrine Abstracts (2010) 21 P31

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Familial GC resistance: a novel, naturally occurring mutation which has dominant negative effects on ligand-dependent and -independent GR action

P Trebble1, L Matthews1, J Blaikley1, A Wayte2, G Black1, A Wilton2 & D Ray1
1Department of Medicine, University of Manchester, Manchester, UK; 2Department of Medicine and Clinical Biochemistry, Ysbyty Gwynedd, Bangor, UK.

Endocrine Abstracts (2010) 21 OC5.1

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Dicer-dependant microRNAs regulate IGF-actions in the human placenta

Karen Forbes, John Aplin & Melissa Westwood
University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 OC4.5

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The spectrum of disease in diazoxide responsive hyperinsulinaemic hypoglycaemia

Mars Skae1, Rakesh Amin1, Leena Patel1, Helena Gleeson1, Sarah Ehtisham1, Mohammed Didi2, Jo Blair2, Urmi Das2, Lindsey Rigby1, Oliver Blankenstein3, Sian Ellard4, Anna Kelsey5, Peter Clayton1,6, Indraneel Banerjee1 & Catherine Hall1
1Department of Paediatric Endocrinology and Diabetes, The New Royal Manchester Children’s Hospital, Manchester, UK; 2Department of Paediatric Endocrinology and Diabetes, Royal Liverpool Children’s Hospital Alder Hey, Liverpool, UK; 3Department of Paediatric Endocrinology and Diabetes, Charite Children’s Hospital, Berlin, Germany; 4Peninsula Medical School, Institute of Biomedical and Clinical Science, Exeter, UK; 5Department of Histopathology, The New Royal Manchester Children’s Hospital, Manchester, UK; 6Endocrine Science Research Group, University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 OC2.7

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Moderate maternal undernutrition results in epigenetic changes in the fetal hypothalamic feeding centres, but not in the fetal HPA axis

Ghazala Begum1, Adam Stevens1, Mark Oliver3, Kristin Connor3, John Challis2, Frank Bloomfield3 & Anne White1
1University of Manchester, Manchester, UK; 2University of Toronto, Toronto, Canada; 3University of Auckland, Auckland, New Zealand.

Endocrine Abstracts (2010) 21 OC1.2

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Mathematical modelling and endocrine research

Julian Davis
Manchester University, Manchester, UK.

Endocrine Abstracts (2010) 21 SB1.3

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Mild primary hyperparathyroidism

Peter Selby
Manchester University, Manchester, UK.

Endocrine Abstracts (2010) 21 CM1.2

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Ubiquitination: the ‘Kiss of Death’ for human growth

Peter E Clayton, Dan Hanson, Philip Murray, Amit Sud & Graeme Black
University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 PL8

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MEN-1 case presentation

Christine Gibson
Manchester Royal Infirmary, Manchester, UK.

Endocrine Abstracts (2010) 21 N1.2

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A psychological aspect of acromegaly

Shashana Shalet
Salford Royal Hospitals NHS Foundation Trust, Salford, UK.

Endocrine Abstracts (2010) 21 N2.3

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A family with functional extraadrenal paragangliomas and positive SDHB gene mutation

Doro Polydorou, Sami Kenz, Daniel Kannapan & Tara Kearney
Salford Royal Foundation Trust, Manchester, UK.

Endocrine Abstracts (2010) 21 P191

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Weight and glycaemic outcomes following bariatric surgery in people with type 2 diabetes

Yared N Demssie1, Jhalini Jawaheer1, Seleena Farook1, John P New1,2 & Akheel A Syed1,2
1Salford Royal NHS Foundation Trust, Salford, UK; 2University of Manchester, Salford, UK.

Endocrine Abstracts (2010) 21 P161

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Extensive hirsutism, a valuable clue to a sinister pathology

Yared Demssie, Annice Mukherjee, Tara Kearney & Akheel A Syed
Salford Royal NHS Foundation Trust, Salford, UK.

Endocrine Abstracts (2010) 21 P41

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Intra Cerebral Haemorrhage in a young woman with Phaeochromocytoma.

Sami Kenz, Doros Polydorou, Daniel Kanappan, Tara Kearney
Hope Hospital, Salford Royal NHS Foundation Trust. Endocrinology Department, Salford, Manchester M6 8HD

Endocrine Abstracts (2010) 21 P235

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A case of thyroid hormone resistance in a family with three generations of thyroid disease

Doros Polydorou, Daniel Kannapan, Sami Kenz, Angela Paisley & Tara Kearney
Salford Royal Foundation Trust, Manchester, UK.

Endocrine Abstracts (2010) 21 P396

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Outcome of treatment for patients with acromegaly in a single referral centre

Sanjaya Dissanayake, Kate Millar, Kalpana Kaushal & Simon Howell
Royal Preston Hospital, Preston, UK.

Endocrine Abstracts (2010) 21 P258

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Carcinomatous change in a craniopharyngioma: a case report

Simeen Akhtar, Aprajay Golash, Windsor Gunawardena, Andrew Hindley & Simon Howell
Royal Preston Hospital, Preston, UK.

Endocrine Abstracts (2010) 21 P257

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Adverse prognosis in breast cancer patients who develop pituitary metastases

Simeen Akhtar, Simon J Howell & Kalpana Kaushal
Royal Preston Hospital, Preston, UK.

Endocrine Abstracts (2010) 21 P254

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Is it pituitary adenoma or metastasis?: an unusual presentation of carcinoma prostate

Daniel Kannappan, Sami Kenz, Doros Polydoro, Tara Kearney & Kanna Gnanalingham
Salford Royal Hospital, Manchester, UK.

Endocrine Abstracts (2010) 21 P248

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Hypopituitarism secondary to pituitary apoplexy- is it due to high dose Aspirin?

Daniel Kannappan, Doros Polydorou, Sami Kenz, Angela Paisley & Tara Kearney
Salford Royal Hospital, Manchester, UK.

Endocrine Abstracts (2010) 21 P242

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Loss of the Golgi localised E3 ubiquitin ligase containing Cullin 7 in the growth disorder 3-M syndrome leads to reduced cell proliferation and reduced IGF1 mediated activation of Akt

Philip Murray1, Daniel Hanson1, Amit Sud1, Ajibola Omokanye1, Waqas Khan2, Naz Khan3, Kate Chandler3, Mona Aglan4, Graeme Black1 & Peter Clayton1
1University of Manchester, Manchester, UK; 2Children’s Hospital Complex, Multan, Pakistan; 3Centran Manchester Foundation Hospitals NHS Trust, Manchester, UK; 4National research Centre, Cairo, Egypt.

Endocrine Abstracts (2010) 21 P232

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Altered responses to GH and IGF1 in children born small for gestational age without post-natal catch up growth

Imogen Butcher, Andrew Whatmore, Philip Murray, Melissa Westwood & Peter Clayton
University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P227

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Pro-opiomelanocortin is a novel biomarker for small cell lung cancer

Rachel Stovold1, Adam Stevens1, David Ray1, Paula Sommers1, Caroline Dive2, Fiona Blackhall2 & Anne White1
1University of Manchester, Manchester, UK; 2Paterson Institute, Manchester, UK.

Endocrine Abstracts (2010) 21 P221

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Investigating the role of HIF-1α in tumour growth and metastasis in an in vivo model of thyroid cancer

Natalie Burrows1, Julia Resch2, Melissa Mejin1, Georg Brabant2 & Kaye Williams1
1School of Pharmacy, University of Manchester, Manchester, UK; 2Department of Endocrinology, Christie Hospital, Manchester, UK.

Endocrine Abstracts (2010) 21 P211

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Impact of adiposity on dynamic changes of serum adipokines after OGTT

Moulinath Banerjee1, Phillip Pemberton2, Valentyn Charlton-Menys1, William Fraser3 & Kennedy Cruickshank1
1Manchester University, Manchester, UK; 2Central Manchester Foundation NHS Trust, Manchester, UK; 3Liverpool University, Liverpool, UK.

Endocrine Abstracts (2010) 21 P122

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Biomarkers of the hypothalamic-pituitary-adrenal (HPA) axis for analysis of in vivo 11β-hydroxysteroid dehydrogenase 1 inhibition

Erika Harno1, Alice Yu2, Brendan Leighton2, Andrew Turnbull2 & Anne White1
1University of Manchester, Manchester, UK; 2CVGI, AstraZeneca, Alderley Park, UK.

Endocrine Abstracts (2010) 21 P171

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Circadian rhythmicity is altered in hepatic corticosterone-related genes from diet induced obese mice

Erika Harno1, Alice Yu2, Henry Brown2, Andrew Turnbull2, Brendan Leighton2 & Anne White1
1University of Manchester, Manchester, UK; 2CVGI, AstraZeneca, Alderley Park, UK.

Endocrine Abstracts (2010) 21 P186

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Choroidal malignant melanoma in a patient with Carney complex

Seleena Farook, Christine Gibson & Julian Davis
Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

Endocrine Abstracts (2010) 21 P201

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Peripheral blood mononuclear cells from active rheumatoid arthritis patients show a defective induction of adrenomedullin

Laura Green, Andrew Berry, Rachelle Donn & David Ray
University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P121

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The relationship between electrolyte disturbance and treatment with proton pump inhibitors

Ana Pokrajac & William Stephens
Trafford General Hospital, Manchester, UK.

Endocrine Abstracts (2010) 21 P97

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An evaluation of the knowledge, motivation and weight-management service needs of obese young people

Marc Williams1, Deborah Kendall2, Helena Gleeson2, Rakesh Amin2, Indi Banerjee2, Sarah Ehtisham2, Leena Patel2, Peter Clayton2,3 & Catherine Hall2
1University of Manchester Medical School, Manchester, UK; 2Royal Manchester Children’s Hospital, Manchester, UK; 3University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P94

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Lithium-induced hypercalcemia and parathyroid dysfunction

Agnieszka Swiecicka & Manjunath Malige
Royal Bolton Hospital, Bolton, UK.

Endocrine Abstracts (2010) 21 P90

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Severe hypomagnesaemia associated with proton pump inhibitor therapy

Sanjaya Dissanayake, Simon Howell, Simon Wallis & Kalpana Kaushal
Royal Preston Hospital, Preston, UK.

Endocrine Abstracts (2010) 21 P83

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